Carla Koehler: Small TIMs are a big deal

Carla Koehler: Small TIMs are a big deal

M itochondria, the cell's power-house organelles, must import most of their component proteins from the cytoplasm. The multipro-tein complexes of the TOM (translocase of outer membrane) and TIM (translocase of inner membrane) families are responsible for this process, with different TOM and TIM proteins working together to guide imported proteins to their proper locations within the organelle. ...

Big Deal - good deal? Or is there a better deal?

Evaluating big deal journal bundles.

Large commercial publishers sell bundled online subscriptions to their entire list of academic journals at prices significantly lower than the sum of their á la carte prices. Bundle prices differ drastically between institutions, but they are not publicly posted. The data that we have collected enable us to compare the bundle prices charged by commercial publishers with those of nonprofit socie...

Book Review: “Cerebral Small Vessel Disease”. What’s the Big Deal about Small Vessels?

Cerebral small vessel disease is perhaps among the most common pathologies in the aging brain, primarily affecting the small perforating arteries and arterioles in the cortex and underlying structures of the white and deep gray matter. Small vessel disease includes hypertensive arteriopathy (arteriolosclerosis, fibrohyalinosis, or lipohyalinosis) and cerebral amyloid angiopathy (injury to the v...

Deal or No Deal? Evaluating Big Deals and Their Journals

This paper presents methods to develop metrics that compare Big Deal journal packages and the journals within those packages. Deal-level metrics guide selection of a Big Deal for termination. Journal-level metrics guide selection of individual subscriptions from journals previously provided by a terminated deal. The paper argues that while the proposed metrics provide helpful quantitative data ...